Ọrịa Gout na Hyperuricemia
Oge okpomọkụ na-ekpo ọkụ, iri nri mmiri, ihe ọṅụṅụ oyi na-atụ oyi na ice, ntụ oyi na-efe efe …… abụghị "ihe ị na-emebu", mana ogologo oge, kpachara anya maka uric acid dị oke elu, na-akpata ọrịa gout!
Gu Bingjie, osote onyeisi dọkịta nke ngalaba rheumatology na immunology nke Ụlọ Ọgwụ Mbụ nke Nanjing, kwuru na n'ime ụbọchị ole na ole gara aga, a na-ahụ ihe fọrọ nke nta ka ọ bụrụ ndị ọrịa 20 nwere hyperuricemia na gout kwa ụbọchị, 90% n'ime ha bụ ụmụ nwoke, afọ ndị a na-amalitekwa ịmalite na-eto eto.
Kedụ ka gout si eme, gịnịkwa mere o ji adịkarị n'ime ụmụ nwoke?
A na-ejikọ gout na ọkwa uric acid dị n'ọbara
Gout, ọrịa mbufụt nke na-esi na ntinye kristal urate n'ime nkwonkwo n'ihi oke uric acid, na hyperuricemia na gout bụ ọnọdụ dị iche iche nke otu ọrịa ahụ.
N'ọnọdụ nkịtị, ahụ ga-amịkọrọ pasentị iri itoolu nke uric acid ahụ, a ga-ewepụkwa pasentị iri fọdụrụ n'ahụ n'ụdị mmamịrị, ọsụsọ, na nsị ka ọkwa uric acid nke ahụ wee nọgide na-enwe nguzozi siri ike. Agbanyeghị, mgbe a na-eri ọtụtụ purines n'ime oke mmepụta nke uric acid, ma ọ bụ enweghị ike iwepụ metabolism uric acid, nguzozi ahụ ga-agbaji, nke na-eme ka uric acid nọgide na-adị n'ọbara, nakwa ka ọbara na-erugharị n'akụkụ niile nke ahụ, na nkwonkwo site na ọbara na-erugharị nwayọ, a ga-etinye obere okpomọkụ iji mepụta kristal urate, na-ebute mmeghachi omume mkpali, na-akpata nnukwu ihe mgbu.
N'ọnọdụ nkịtị, ahụ ga-amịkọrọ pasentị iri itoolu nke uric acid ahụ, a ga-ewepụkwa pasentị iri fọdụrụ n'ahụ n'ụdị mmamịrị, ọsụsọ, na nsị ka ọkwa uric acid nke ahụ wee nọgide na-enwe nguzozi siri ike. Agbanyeghị, mgbe a na-eri ọtụtụ purines n'ime oke mmepụta nke uric acid, ma ọ bụ enweghị ike iwepụ metabolism uric acid, nguzozi ahụ ga-agbaji, nke na-eme ka uric acid nọgide na-adị n'ọbara, nakwa ka ọbara na-erugharị n'akụkụ niile nke ahụ, n'ime nkwonkwo site na ọbara na-erugharị nwayọ, a ga-etinye obere okpomọkụ, ka ọ mepụta kristal urate, nke na-ebute mmeghachi omume mkpali, na-akpata nnukwu ihe mgbu.
Gịnị mere gout ji "enwe mmasị" n'ebe ụmụ nwoke nọ karịsịa?
Na mgbakwunye, nnyocha egosila na homonụ, dịka ndị na-achịkwa metabolism dị mkpa, na-arụ ọrụ na mmepụta na mwepụta nke uric acid, gụnyere homonụ mmekọahụ, hormone adrenocorticotropic, hormone thyroid, insulin, na ndị ọzọ. Mgbe usoro endocrine na-adịghị arụ ọrụ nke ọma, mmepụta ma ọ bụ ọrụ nke homonụ ndị a nwere ike imetụta, na-eduga na mmụba nke ọkwa uric acid, nke na-akpali mmepe nke gout.
E nwekwara ọdịiche dị n'etiti homonụ dị n'etiti ụmụ nwoke na ụmụ nwanyị, ebe androgens na-abụkarị ndị ikom na ụmụ nwanyị, estrogen na-emekwa ka uric acid gbapụta ma gbochie mmepụta urate. N'aka nke ọzọ, Androgens na-egbochi mwepụta uric acid n'ime akụrụ ma belata arụmọrụ metabolic akụrụ, na-eduga n'ọkwa uric acid dị elu n'ahụ, si otú a na-eme ka mmepụta na itinye kristal uric acid dịkwuo ngwa ngwa. Data na-egosi na n'etiti ndị mmadụ n'ozuzu, ihe karịrị 95% nke gout na-eme n'ime ụmụ nwoke, ihe na-eme n'ime ụmụ nwanyị bụ naanị ihe na-erughị 5%, na oke nke ụmụ nwoke na ụmụ nwanyị dị nso na 20:1.
Kedu ka m ga-esi belata ohere m nwere ibute gout?
Ọ bụghị naanị nke ahụ, ihe gbasara gout ma ọ bụ hyperuricemia na-ejikọkwa aka na nri na-adịghị mma na àgwà ndụ na-adịghị mma. Ya mere, iji belata ihe ize ndụ nke gout, ị nwere ike igbochi ya kwa ụbọchị site n'ime ihe ndị a:
- Jikwaa ọnụ gị: Zere iri nri purine dị elu, ị nwere ike iri nri alkaline karịa iji melite mmiri uric acid dị na mmamịrị ma mee ka uric acid a na-ewepụta dịkwuo elu.
- Na-aṅụkwu mmiri: N'oge ọkọchị, ahụ́ mmadụ na-agba ọsụsọ nke ukwuu, ọ bụrụkwa na ọ naghị adị mmiri mmiri n'oge, ọ na-eme ka ọbara gbapụta ngwa ngwa, ọkwa uric acid dị n'ọbara na-arịkwa elu nke ọma, nke na-akpata gout.
- Njikwa Ibu: Oke ibu abụghị naanị ọrịa metabolic, kamakwa ọ bụ ihe nwere ike ibute hyperuricemia na gout n'ihi na mkpụrụ ndụ abụba na-ewepụta ọtụtụ purines, nke na-eme ka ọkwa uric acid dịkwuo elu.
- Megharịa ụkwụ gị: Nnyocha ndị mba ọzọ egosila na mmega ahụ aerobic dị obere kwa ụbọchị (dịka ịga ije ngwa ngwa, ịgba ọsọ, igwu mmiri, wdg) maka nkeji iri atọ ruo iri isii, ugboro anọ ruo ise n'izu, nwere ike ibelata ihe mgbu nke gout.
Ọmụmụ ihe na-egosi na ọkụ uhie nwere ike ime ka mgbaàmà gout belata
E wezụga ịnọgide na-ebi ndụ dị mma, n'usoro ọgwụgwọ nke gout, nkwonkwo ndị gbawara agbawa, na ihe mgbu na-aghọ nsogbu kachasị nye onye ọrịa, e nwere ọtụtụ akwụkwọ sayensị na-egosi na ndị ọrịa gout na-agwọ ọkụ uhie nwere ike imeziwanye metabolism nke anụ ahụ, mee ka mgbake nke akwara mebiri emebi ngwa ngwa, ma belata oge ọzịza na ihe mgbu nke ọma iji belata ihe mgbu anụ ahụ na nke uche nke onye ọrịa, ma kwalite usoro mgbake, na n'ọmụmụ ihe ahụike n'oge na-adịbeghị anya gosiri na 88% nke ndị ọrịa nwere gout mgbe ọgwụgwọ ọkụ uhie gasịrị emeela ka ihe mgbu ka mma nke ukwuu, ọbụna nweta mmetụta nke mbelata mgbu zuru oke. N'ọmụmụ ihe ahụike n'oge na-adịbeghị anya, egosiri na 88% nke ndị ọrịa gout nwere nnukwu mmụba na ihe mgbu mgbe ọgwụgwọ ọkụ uhie gasịrị, ọbụna nweta mmetụta nke mbelata mgbu zuru oke.
Ọtụtụ nnyocha ahụike gosikwara na ahụ nwere ike ịmịnye ìhè uhie ma banye n'ime ahụ nke ọma, nwee ike ịkpalite uto nke axon akwara akụkụ mebiri emebi, nke mere na nhazi nke mkpuchi myelin akwara na-eme ka mmezi na mmeghari akwara akụkụ mebiri emebi dịkwuo ngwa ngwa, n'otu oge ahụ, radieshon ìhè uhie nwere ike ime ka anụ ahụ mpaghara nke ọdịnaya pentazocine belata, wee si otú a rụọ ọrụ nke analgesia, nke na-enyere aka belata ihe mgbu.
Ụlọ Ahụike MERICAN nke dabere na ọgwụgwọ ọkụ uhie na-ejikọta ọtụtụ ebili mmiri ìhè kpọmkwem iji mepụta mmetụta bayọlọji na akpụkpọ ahụ nke ahụ dum, nke nwere ike ime ka metabolism anụ ahụ na ọnọdụ nri ka mma, mee ka phagocytosis na ikike vaskụla dịkwuo mma, ma gbochie ngosipụta nke cytokines metụtara ihe mgbu nke ọma, nke na-eme ka mmịpụta nke ihe ndị na-akpata mbufụt pụta, belata ihe mgbu nkwonkwo onye ọrịa, belata index nke uric acid ọbara, ma kwalite mmezi nke mgbaàmà ahụike na mgbake nkwonkwo.
Taa, gout abụrụla "nke anọ kachasị elu" mgbe ọrịa shuga, ọbara mgbali elu na oke abụba gasịrị. Dabere na ụdị ndụ sayensị na ahụike, nke ejiri ọgwụgwọ ọkụ uhie mee, ọ nwere ike ibelata mgbaàmà ndị na-adịghị mma ma si otú a kwalite usoro mgbake nke ọma.